Martha Spencer grew up in a musical family in Whitetop Mountain, Virginia. At an early age, she began flatfoot dancing and singing, and learned to play several instruments (guitar, banjo, fiddle, bass, mandolin, and dulcimer. She plays in several groups – with her family, the Whitetop Mountain Band, with Larry Sigmon in Unique Sound of the Mountains, in duo group the Whitetop Mountaineers and trio group Spencer Branch, and in the Old Time Country Roadshow, as well as writing and recording on her own. She has toured across the United States and abroad many times. She is also active in passing on the music to youth in the area, working with JAM and the Albert Hash Memorial Stringband. She also has worked with several projects including Mountain Music Magazine, Backroads of America show, and Country Songbird Collective.